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Original Article
Year : 2021  |  Volume : 9  |  Issue : 4  |  Page : 49-71

Simultaneous spectrophotometric estimation of atenolol and chlorthalidone in tablet dosage form

The accurate, precise, sensitive, and economical spectrophotometric method was developed and validated for simultaneous estimation of atenolol (ATN) and chlorthalidone in tablet dosage form. The ultraviolet method employed was simultaneous equation method. The method employs 318 nm as λ1 and 290 nm as λ2 for the formation of equations. ATN and chlorthalidone obeys Beer’s law in the concentration range 10-160 μg/mL−1 (r2 = 0.9957) and 5-25 μg/mL−1 (r2 = 0.9965). The mean recovery for ATN and chlorthalidone was found to be 100.11 ± 0.483% and 100 ± 0.534%, respectively. The developed method was validated according to ICH guidelines and values of accuracy, precision, and other statistical analysis were found to be in good accordance with the prescribed values. Thus, the proposed methods were successfully applied for simultaneous determination of ATN and chlorthalidone in routine industrial work.
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