JPBS
× About the Journal Scope of the Journal SPER Publications Editorial Board Abstracting and Indexing Articles in Press Current Issue Archives Submit Article Author Guidelines Advertise Join as Reviewer Contact Editorial Policies and Peer Review Process Journal Policies Publishing Ethics
 

Original Article
Year : 2017   |  Volume : 5  |  Issue : 4  |  Page : 38-43

Preparation and evaluation of mucoadhesive buccal tablet for oral infection disease

In recent years, significant interest has been shown in the development of novel bioadhesive dosage forms for mucosal delivery of drugs. A drug administered through the buccal mucosa enters directly to the systemic circulation, thereby minimizing the first-pass hepatic metabolism and adverse gastrointestinal effect. The objective of the project was to develop a stable and robust formulation of buccal tablet of the selected antifungal drug miconazole nitrate for the treatment of oral candidiasis. Oral candidiasis is an opportunistic infection of the mouth, highly prevalent in a specific group of patients including AIDS patients. Without treatment, the lesion may spread to the esophagus, causing invasive esophageal candidiasis, which is categorized as an AIDS-defining illness. Miconazole nitrate has a broad-spectrum of activity against most pathogenic fungi and Gram-positive bacteria. The drug has poor aqueous solubility. It has the potential to be used in the treatment of all forms of both mucosal and systemic candidiasis. The result of the project would provide a process that would provide stable formulation of buccal tablet. In this project, buccal tablet was prepared by direct compression. Among different trials with direct compression, the trial batch showed satisfactory in vitro drug release profile as compared to that of innovator for sustained release formulation.
[]*
Print this article     Email this article

 

Contact SPER Publications


SPER Publications and Solutions Pvt. Ltd.

#730, Tower B, i-Thum IT Park,
Sector 62, Noida,
Uttar Pradesh 201301 [Delhi-NCR] India
Phone: +91-930-190-7999 / +91-120-410-0035
E-mail: journals@sperpublications.com
Website: www.sperpublications.com