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Abstract


JOURNAL OF PHARMACEUTICAL AND BIOSCIENCES - Volume 1, Issue 1 , January-March 2013

Pages: 01-03

Magainin, isolated from Xenopuslaevis, induced Apoptosis in Human Cervical Carcinoma Cells.

Author: MukeshBansal, Santosh Gupta, Umesh S. Pal, Abhishek Pal

Category: Original research

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Abstract:

Magainins are a family of potent antimicrobial cationic peptides that possess antimicrobial activity, anti-tumour activity,although the anticancer mechanism is still unclear. We investigated the effects of Magainins on apoptosis induction in human cervical carcinoma (HeLa) cells. Lapachone, an anticancer drug, was used as a positive control. The results demonstrated that Magainins inhibited proliferation of HeLa cells in a dose-dependent manner and had greater efficacy than that of lapachone. IC50 values of the test compound ranged from 1.2±0.1 to 5.5±0.86 M for 2 to 24 h time periods.

Keywords: Magainin, Human Cervical Carcinoma Cells, Apoptosis

DOI: 26-feb-2013

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2013 0.386
2014 0.454
2015 0.565

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Cosmos Impact Factor 2015  2.563

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