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JOURNAL OF PHARMACEUTICAL AND BIOSCIENCES - Volume 1, Issue 4 , October-December 2013

Pages: 124-127

Evaluation of anti-proliferative activities of ethanolic extracts of Sarcocephaluslatifoluis fruit and Paullina pinnata leaf

Author: D. Arome and E. Chinedu

Category: Original research

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Scientific investigations over the years have indicated herbal preparations to be effective against wide range of diseases with little or no side effects associated with their use. Herbal preparations have very special features that differentiatethem from other chemicals. The present study was carried out to investigate the anti-proliferative activities of ethanolic extracts of Sarcocephalus latifoluis fruit and Paulina pinnata leaf on radicle length of fast growing Sorghum bicolor seeds. The extracts were prepared at three concentrations of 1000, 2000 and 3000 μg/ml. The radicle lengths of seeds were measured at 24 and 48 hours of the experiment. The extracts produced significant anti- proliferative activity against the radicle length of the Sorghum bicolor seeds. The anti-proliferative activity of the extracts do not follow concentration dependent pattern. The extracts significantly slowed down the proliferation of the Sorghum bicolor at the applied concentrations. The anti-proliferative activities of the extracts were significant (P < 0.001) at the 48th hours of the experiment. The standard reference methotrexate produced significant (P < 0.01) anti-proliferative activity at the 24th and 48th hours compared to the extracts groups. The results of the experiment elucidate the anti-proliferative activity of ethanolic extracts of Sarcocephalus latifoluis fruit and Paullina pinnata leaf.

Keywords: Anti-proliferative activity, Sarcocephalus Latifoluis, Paulina pinnata Sorghum bicolor, methotrexate.

DOI: 20 January 2014

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