Inhibition of a-glucosidase enzyme by Parsley crispum L. leaf extract: Possible role in controlling postprandial hyperglycemia

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DOI: 10.4103/2231-4040.197331

Inhibition of intestinal a glucosidase for preventing rise in postprandial glucose level in diabetics forms an integral part of the management of diabetes. Parsley leaves extract (PLE) in the present study was explored for the same. The chemical analysis of extract revealed the presence of tannins, flavonoids, sterols and triterpenes. In this preliminary study PLE showed promising effects in in vitro test using isolated a glucosidase enzyme from rat intestine and in vivo study using different doses of PLE were carried against a sucrose load of 2.5 g/kg body weight in rats. The maximum inhibition of a- glucosidase produced by the extract was upto 80%. The extract exhibited a dose dependent reduction in glucose level with a maximum response being observed was shown by 400 and 800 doses of PLE at intervals of 120 and 180 mins. This effect of PLE indicates that it has a potential in preventing postprandial hyperglycemia. In conclusion the extract of parsley leaves possesses the excellent antihyperglycemic effect and this may be mediated by a glucosidase inhibition. These results suggest that PL extract can provide an effective remedy for managing postprandial hyperglycemia in a more safe and cost effective manner.

Keywords: Parsley leaf extract, Postprandial hyperglycemia, Inhibitor of a glucosidase enzyme, Diabetes mellitus