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Year : 2013   |  Volume : 1   |  Issue : 1   |  Page : 1-3  

Magainin, isolated from Xenopus laevis, induced Apoptosis in Human Cervical Carcinoma Cells

Mukesh Bansal*, Santosh Gupta, Umesh S. Pal and Abhishek Pal

Correspondence Address:Pacific College of Pharmacy, Udaipur, Rajasthan, India

Source of Support: , Conflict of Interest: None


DOI: 10.4103/2231-4040.197331

Abstract  

Magainins are a family of potent antimicrobial cationic peptides that possess antimicrobial activity, anti-tumour activity, although the anticancer mechanism is still unclear. We investigated the effects of Magainins on apoptosis induction in human cervical carcinoma (HeLa) cells. Lapachone, an anticancer drug, was used as a positive control. The results demonstrated that Magainins inhibited proliferation of HeLa cells in a dose-dependent manner and had greater efficacy than that of lapachone. IC50 values of the test compound ranged from 1.2±0.1 to 5.5±0.86 µM for 2 to 24 h time periods

Keywords: Magainin, Human Cervical Carcinoma Cells, Apoptosis

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