× About the Journal Scope of the Journal SPER Publications Editorial Board Abstracting and Indexing Articles in Press Current Issue Archives Submit Article Author Guidelines Advertise Join as Reviewer Contact Editorial Policies and Peer Review Process Journal Policies Publishing Ethics

2014 2 3 63-71
Year : 2021  |  Volume : 9   |  Issue : 4   |  Page : 49-71  

Preparation, Characterization and In Vitro Evaluation of Novel Gellan Gum-Raloxifene HCl Nanoparticles

S. Jaya Prakash, A. Santhiagu, S. Jasemine

Correspondence Address:Bioprocess Laboratory, School of Biotechnology, National Institute of Technology, Calicut-673601, Kerala, India. Department of Pharmaceutical Chemistry, National College of Pharmacy, Calicut-673602, Kerala, India.

Source of Support: , Conflict of Interest: None

DOI: 10.4103/2231-4040.197331


Raloxifene HCl is a BCS (Biopharmaceutics Classification System) class-II drug with low solubility and poor bioavailability (2%). The present study was undertaken to develop a nanoparticles system using the biopolymer gellan which has not been explored well for its direct use in nanoparticulate systems. Gellan gum nanoparticles encapsulated with raloxifene HCl was prepared by emulsion cross linking method and the developed nanoparticles showed narrow particle size distribution with an average size of 472 nm, zeta potential of -40.6 mV along with 98±3% entrapment efficiency. FTIR studies demonstrated chemical interaction between the polymer and drug. In vitro release studies showed an initial burst release within 30 min followed by a continuous release for 24 hours. In vitro cytotoxicity studies performed with MCF7 cell line revealed that the raloxifene HCl-gellan gum nanoparticles exhibited higher cytotoxicity compared to free raloxifene HCl.

Keywords: Polymer Nanoparticles, Biopolymer, Gellan Gum, Sphingomonas Paucimobilis, Drug Delivery, Raloxifene HCl

How to cite this article:
Kanke PK, Pathan IB, Jadhav A, Usman MRM. Formulation and evaluation of febuxostat nanoemulsion for transdermal drug delivery. J Pharm BioSci 2021;9(4):49-71

Contact SPER Publications

SPER Publications and Solutions Pvt. Ltd.

#730, Tower B, i-Thum IT Park,
Sector 62, Noida,
Uttar Pradesh 201301 [Delhi-NCR] India
Phone: +91-120-410-0035