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Year : 2013   |  Volume : 1   |  Issue : 1   |  Page : 7-18  

Formulation and evaluation of solid–lipid nanoparticle based 0.1% Soy isoflavone dermal gels

Ketkee Deshmukh and Purnima Amin

Correspondence Address:Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, M. S., India

Source of Support: , Conflict of Interest: None


DOI: 10.4103/2231-4040.197331

Abstract  

Solid – Lipid Nanoparticles (SLNs) based 0.1 % topical gel of soy isoflavones was formulated with the aim of better penetration through stratum cornea and efficient deposition of soy isoflavones in dermal matrix so as to aid in reversing postmenopausal skin aging. Isoflavoneaglycones were extracted from whole herbal soy extract and were characterized with respect to physical, spectral and antioxidant activity. SLNs prepared by microemulsion template technique were characterized by photon correlation spectroscopy for size and by Scanning Electron Microscopy for morphology. The nanoparticulate dispersion was suitably gelled and characterized with respect to pH, spreadability, rheology, drug content, in-vitro permeation using pig ear skin model and its safety was assessed using primary skin irritation studies. The developed SLN-based gel showed about 60% deposition of soy isoflavones in dermal matrix and showed no skin irritation on intact rabbit skin.

Keywords: Nanostructured Nanomaterial, Solid – Lipid Nanoparticles, Topical Gel, Soy Isoflavones, Draize Patch Test

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