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Journal of Pharmaceutical and BioSciences

 
Year : 2013   |  Volume : 1  |  Issue : 1  |  Page : 36-43

Novel therapeutic approaches for Alzheimer’s disease

Anand Pendse and Rashmi Vohra
The currently approved therapies for Alzheimers disease (AD) in the US are designed to modify the function of specific neurotransmitter systems in the brain. While these palliative treatments can benefit some patients for a period of time, they do not halt the relentless cognitive and behavioral deterioration that characterize this neurodegenerative disorder. Alzheimers disease (AD) and vascular dementia (VaD) are both associated with deficits in cholinergic neurotransmission that are amenable to therapeutic intervention. The cholinesterase inhibitor, donepezil, is clinically effective in both AD and VaD. There are various additional therapies which might be useful, if the diagnosis and treatment is started at the early stage.
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