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Journal of Pharmaceutical and BioSciences

Year : 2013   |  Volume : 1   |  Issue : 2   |   Page : 48-50  

Quantitative Determination of Finasteride from Tablet Formulation by UV-Spectrophotometry

Mukesh Bansal, Pawan Rathore , Bharat Goel

Correspondence Address:Pacific College of Pharmacy, Udaipur (Raj.), India., Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, U.P., India

Source of Support: , Conflict of Interest: None


DOI: 10.4103/2231-4040.197331

Abstract  

A simple, accurate and economical UV-Spectrophotometric method has been developed for routine analysis of Finasteride Hydrochloride in tablet. Finasteride showed maximum absorbance at 287.0 nm in saline phosphate buffer (PBS) pH 7.4. In this method, Finasteride obeyed linearity in the concentration range of 2-20 µg/mL with a correlation coefficient of 0.9998. The limit of detection and Limit of Quantification for finasteride was found to be 0.82µg/ml and 2.76µg/ml respectively. The percentage recovery was found to be 99.3% and showed good repeatability with relative standard deviation less than 2. Methods were validated statistically using the principle of least squares by the equation Y = 0.080 X – 0.007.

Keywords: Finasteride, Phosphate buffer, UV-Spectrophotometry

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