NOVEL APPROACHES FOR SOLIDIFICATION OF SMEDDS

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DOI: 10.4103/2231-4040.197331

SMEDDS are isotropic mixtures of drug, oil, surfactant and co-surfactant that have unique ability of forming fine o/w micro-emulsion upon mild agitation followed by dilution in aqueous media, such as GI fluid. SMEDDS is the one of the approach to improve the solubility as well as the bioavailability of drug. There are different techniques used for conversion of liquid SMEDDS into solid SMEDDS such as spray drying, melt extrusion, adsorption to solid carrier, extrusion spheronisation, encapsulation of solid and semisolid SEDDS, etc. The present review highlights the various novel approaches for solidification of SMEDDS

Keywords: SMEDDS, Bioavailability, Oil, Surfactant, Co-surfactant, Novel approaches