Evaluation of cardiovascular effects and cardiotonic activity of Phyllanthus amarus and Phyllanthus fraternus

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DOI: 10.4103/2231-4040.197331

A great number of preclinical and clinical studies have not only confirmed but have also extended the medicinal uses of species of the genus Phyllanthus mentioned in traditional medicine. While effects of the extracts of Phyllanthus amarus & Phyllanthus fraternus on cardiovascular system using their different concentrations has not been previously reported. The cardiovascular activity was evaluated by using isolated frog heart perfusion technique. The extracts of P. amarus & P. fraternus at a dose of (50-200 µg/ml) had no effect on the cardiovascular system of normal frog heart whereas, when given to a hypodynamic heart the extracts improved its function. The current study reveals the cardiotonic activity of extracts of P. amarus & P. fraternus by improving the function of a hypodynamic heart. Digoxin was used as a positive control.

Keywords: Phyllanthus amarus, Phyllanthus fraternus, Cardiotonic activity and Digoxin